POTENSI NUTRASETIKAL SEBAGAI TERAPI PENDAMPING KANKER PAYUDARA: TELAAH SISTEMATIS
Abstract
Globally, breast cancer stands as the most common cancer and the leading cause of death for women. Currently, breast cancer treatment strategies focus more on the evaluation of clinical and pathological parameters rather than gene expression criteria. With advances in medical science and nutrition, great attention is being paid to foods and natural products that can improve health. Bioactive nutrients that provide protective benefits against breast cancer include polyphenols, retinoids, and polyunsaturated fatty acids (PUFAs). These compounds possess antioxidant, anti-inflammatory, immunomodulatory, and antitumor properties. Specific substances such as resveratrol, epigallocatechin 3-gallate, retinoids, and omega-3 PUFAs influence the characteristics of breast cancer and are involved in various cancer processes, including cell growth inhibition, inflammation, and angiogenesis.
Keywords
Full Text:
PDFReferences
Ahmed, A., Redmond, H. P., & Wang, J. H. (2013). Links between Toll-like receptor 4 and breast cancer. Oncoimmunology, 2(2), e22945. https://doi.org/10.4161/onci.22945
Almatrood, S. A., Almatroudi, A., Khan, A. A., Alhumaydh, F. A., Alsahl, M. A., & Rahmani, A. H. (2020). Potential therapeutic targets of epigallocatechin gallate (EGCG), the most abundant catechin in green tea, and its role in the therapy of various types of cancer. Molecules, 25(14). https://doi.org/10.3390/molecules25143146
Augimeri, G., Montalto, F. I., Giordano, C., Barone, I., Lanzino, M., Catalano, S., Andò, S., De Amicis, F., & Bonofiglio, D. (2021). Nutraceuticals in the Mediterranean Diet: Potential Avenues for Breast Cancer Treatment. Nutrients, 13(8), 2557. https://doi.org/10.3390/nu13082557
Bollag, W., & Holdener, E. E. (1992). Review Retinoids in cancer prevention and therapy. Annals OfOncology 3: 513-526, April, 513–526.
Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 68(6), 394–424. https://doi.org/10.3322/caac.21492
Doldo, E., Costanza, G., Agostinelli, S., Tarquini, C., Ferlosio, A., Arcuri, G., Passeri, D., Scioli, M. G., & Orlandi, A. (2015). Vitamin A, cancer treatment and prevention: The new role of cellular retinol binding proteins. BioMed Research International, 2015(May). https://doi.org/10.1155/2015/624627
Geng, L., Zhou, W., Liu, B., Wang, X., & Chen, B. (2018). Dha induces apoptosis of human malignant breast cancer tissues by the TLR-4/PPAR-α pathways. Oncology Letters, 15(3), 2967–2977. https://doi.org/10.3892/ol.2017.7702
Ghoneum, M. H., Badr El-Din, N. K., Abdel Fattah, S. M., Pan, D., & Tolentino, L. (2015). Hydroferrate fluid, MRN-100, provides protection against chemical-induced gastric and esophageal cancer in Wistar rats. In International journal of biological sciences (Vol. 11, Issue 3, pp. 295–303). https://doi.org/10.7150/ijbs.10586
Goldhirsch, A., Wood, W. C., Coates, A. S., Gelber, R. D., & Thu, B. (2011). Strategies for subtypes — dealing with the diversity of breast cancer : highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011. June, 1736–1747. https://doi.org/10.1093/annonc/mdr304
Hesari, A. R., Azizian, M., Darabi, H., Nesaei, A., Hosseini, S. A., Salarinia, R., Motaghi, A. A., & Ghasemi, F. (2019). Expression of circulating miR-17, miR-25, and miR-133 in breast cancer patients. Journal of Cellular Biochemistry, 120(5), 7109–7114. https://doi.org/10.1002/jcb.27984
Hunsu, V. O., Facey, C. O. B., Fields, J. Z., & Boman, B. M. (2021). Retinoids as Chemo-Preventive and Molecular-Targeted Anti-Cancer Therapies.
Jäger, W., Gruber, A., Giessrigl, B., Krupitza, G., Szekeres, T., & Sonntag, D. (2011). Metabolomic analysis of resveratrol-induced effects in the human breast cancer cell lines MCF-7 and MDA-MB-231. OMICS A Journal of Integrative Biology, 15(1–2), 9–14. https://doi.org/10.1089/omi.2010.0114
Kamran, M. Z., Patil, P., & Gude, R. P. (2013). Role of STAT3 in cancer metastasis and translational advances. BioMed Research International, 2013. https://doi.org/10.1155/2013/421821
Kohandel, Z., Farkhondeh, T., Aschner, M., Pourbagher-Shahri, A. M., & Samarghandian, S. (2021). STAT3 pathway as a molecular target for resveratrol in breast cancer treatment. Cancer Cell International, 21(1), 1–9. https://doi.org/10.1186/s12935-021-02179-1
Kotha, A., Sekharam, M., Cilenti, L., Siddiquee, K., Khaled, A., Zervos, A. S., Carter, B., Turkson, J., & Jove, R. (2006). Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein. Molecular Cancer Therapeutics, 5(3), 621–629. https://doi.org/10.1158/1535-7163.MCT-05-0268
Loizzo, M. R., & Tundis, R. (2019). Plant antioxidant for application in food and nutraceutical industries. Antioxidants, 8(10), 14–17. https://doi.org/10.3390/antiox8100453
Nasri, H., Baradaran, A., Shirzad, H., & Kopaei, M. R. (2014). New concepts in nutraceuticals as alternative for pharmaceuticals. International Journal of Preventive Medicine, 5(12), 1487–1499.
Nishida, C., Uauy, R., Kumanyika, S., & Shetty, P. (2004). The Joint WHO/FAO Expert Consultation on diet, nutrition and the prevention of chronic diseases: process, product and policy implications. Public Health Nutrition, 7(1a), 245–250. https://doi.org/10.1079/phn2003592
Pfeffer, C. M., & Singh, A. T. K. (2018). Apoptosis: A Target for Anticancer Therapy. In International Journal of Molecular Sciences (Vol. 19, Issue 2). https://doi.org/10.3390/ijms19020448
Sofi, F., Macchi, C., Abbate, R., Gensini, G. F., & Casini, A. (2013). Review Article Mediterranean diet and health status : an updated meta-analysis and a proposal for a literature-based adherence score. 17(12), 2769–2782. https://doi.org/10.1017/S1368980013003169
Suh, J., Kim, D. H., & Surh, Y. J. (2018). Resveratrol suppresses migration, invasion and stemness of human breast cancer cells by interfering with tumor-stromal cross-talk. Archives of Biochemistry and Biophysics, 643(February), 62–71. https://doi.org/10.1016/j.abb.2018.02.011
World Health Organization. (2022). Breast cancer. https://www.who.int/news-room/fact-sheets/detail/breast-cancer
Zan, L., Chen, Q., Zhang, L., & Li, X. (2019). Epigallocatechin gallate (EGCG) suppresses growth and tumorigenicity in breast cancer cells by downregulation of miR-25. Bioengineered, 10(1), 374–382. https://doi.org/10.1080/21655979.2019.1657327
Zanardi, S., Serrano, D., Argusti, A., Barile, M., Puntoni, M., & Decensi, A. (2006). Clinical trials with retinoids for breast cancer chemoprevention. 51–68. https://doi.org/10.1677/erc.1.00938
DOI: http://dx.doi.org/10.62870/tmj.v4i2.29475
Refbacks
- There are currently no refbacks.
Copyright (c) 2025 Sefanadia Putri
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Manage by Faculty of Medicine, Universitas Sultan Ageng Tiryatasa
Publish by: Universitas Sultan Ageng Tiryatasa
Address : Jl. Raya Palka No.Km 3, Panancangan, Kec. Cipocok Jaya, Serang, Banten 42124, Indonesia
Tirtayasa Medical Journal (E-ISSN 2809-5111) is licensed under a Creative Commons Attribution 4.0 International License. Preserved in LOCKSS, through PKP Private LOCKSS Network program.