A Case Control Study on The Relationship Between Bodey Mass Index as a Risk Factors for Incidence of Cholelithiasis at RSUD Banten
Abstract
Cholelithiasis is a condition where stones form in the gallbladder or bile ducts and its prevalence is increasing in Indonesia. Various risk factors have been identified, with high Body Mass Index (BMI) being one of the dominant risk factors. This study aims to analyze the relationship between BMI and the incidence of Cholelithiasis in various age groups at Banten Regional Hospital. The study used a case-control design with 80 respondents (40 cases and 40 controls) taken from the medical record data of Banten Regional Hospital for the period January 2023-May 2024. Data analysis used Chi-Square test with a significance level of α=0.05. The results showed that in the case group, the majority of respondents had excessive BMI (≥23 kg/m²) as much as 75.0%, while in the control group as much as 42.5%. There is a significant relationship between BMI and the incidence of Cholelithiasis (p=0.025) with a risk of 4.182 times greater in patients with excess BMI than underweight BMI. Analysis in various age groups showed that the relationship between BMI and Cholelithiasis was significant in the young adult age group (18-40 years) with p=0.039, but not significant in the middle adult age group (41-60 years) and the elderly (>60 years). In conclusion, excess BMI is a significant risk factor for Cholelithiasis, with a stronger association in the young adult age group. This study provides scientific evidence of the importance of weight management in Cholelithiasis prevention strategies, especially in the young adult age group.
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REFERENCES
Arikunto, Suharsimi. (2016). Research Procedures A Practical Approach. Jakarta: PT Rineka Cipta.
Chen, C. H., Lin, C. L., & Kao, C. H. (2019). Association between gallbladder stone disease and prostate cancer: A nationwide population-based study. Oncotarget, 7(39), 64380-64389.
Dani, L. S. (2012). Characteristics of Cholelithiasis Patients at Immanuel Hospital Bandung Period January 1, 2012 - December 31, 2012. Faculty of Medicine, Maranatha Christian University, 1-6.
Di Ciaula, A., Wang, D. Q. H., & Portincasa, P. (2018). An update on the pathogenesis of cholesterol gallstone disease. Current Opinion in Gastroenterology, 34(2), 71-80.
Febyan, F., Ndraha, S., & Tendean, M. (2017). Characteristics of Patients with Cholelithiasis Based on Risk Factors at Koja Hospital. Meditek Medical Journal, 23(61), 37-47.
Fitzgerald, J. E. F., Fitzgerald, L. A., Maxwell-Armstrong, C. A., & Brooks, A. J. (2009). Recurrent gallstone ileus: Time to change our surgery? Journal of Digestive Diseases, 10(2), 149-151.
Jayedi, A., Soltani, S., Zargar, M. S., Khan, T. A., & Shab-Bidar, S. (2020). Central fatness and risk of all cause mortality: Systematic review and dose-response meta-analysis of 72 prospective cohort studies. BMJ, 370, m3324.
Jessri, M., & Rashidkhani, B. (2015). Dietary patterns and risk of gallbladder disease: A hospital-based case-control study in adult women. Journal of Health, Population and Nutrition, 33(1), 39-49.
Ministry of Health RI. (2018). Basic Health Research (RISKESDAS) 2018. Jakarta: Agency for Health Research and Development.
Lammert, F., Gurusamy, K., Ko, C. W., Miquel, J. F., Méndez-Sánchez, N., Portincasa, P., et al. (2016). Gallstones. Nature Reviews Disease Primers, 2, 16024.
Shabanzadeh, D. M., Sørensen, L. T., & Jørgensen, T. (2017). Determinants for gallstone formation - a new data cohort study and a systematic review with meta-analysis. Scandinavian Journal of Gastroenterology, 51(10), 1239-1248.
Stinton, L. M., & Shaffer, E. A. (2012). Epidemiology of gallbladder disease: Cholelithiasis and cancer. Gut and Liver, 6(2), 172-187.
Wang, H. H., Portincasa, P., de Bari, O., Liu, K. J., Garruti, G., Neuschwander-Tetri, B. A., et al. (2018). Prevention of cholesterol gallstones by inhibiting hepatic biosynthesis and intestinal absorption of cholesterol. European Journal of Clinical Investigation, 43(4), 413-426.
Wang, Q., Jiao, L., He, C., Sun, H., Cai, Q., Han, T., et al. (2017). Alteration of gut microbiota in association with cholesterol gallstone formation in mice. BMC Gastroenterology, 17(1), 1-9.
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