Production of Poly Lactic Glycolic Acid from Solid Waste of Palm Starch Industry for Applications in the Field of Medical Biomaterials

Sari Purnavita




Palm starch industry bring out solid waste that contain high total cellulose (cellulose and hemicellulose), that is 82,03%. Cellulose from solid waste of palm starch industry can be used in lactic acid production through hydrolysis and fermentation processes. Enzymatic hydrolysis and fermentation processes will work efficient and effectively when run simultaneously in one reactor, known as Simultaneous Sacharificatian and Fermentation (SSF). This research aimed to find out the most effective pH and quantity of inoculum in SSF process. This research was using substrate from solid waste of palm starch industry that treated by delignification using NaOH 7% and then saccharificated and fermented simultaneously using enzyme from Trichodermareesei for saccharification process, and Lactobacillus delbrueckii bacteria FNCC 0045 for lactic acid fermentation. The research was held by pH variation of 4, 5, 6 and 7, while quantity of inoculum were 5, 10, 15, 20 and 25% respectively. The incubation was at 46°C for 96 hour. The result showed that optimal pH was 6 and 25% inoculum was the best. Production of PLGA films was started with the polymerization reaction between lactic acid and glycolic acid at various ratios of monomer (wt%) = 95:5 and PLGA :PVA at various ratio (wt%)= 3:2, 3:3, 3:4, 3:5.The solution of PLGA in chloroform was added with PVA solution (as the film forming agents) and aloe vera gel (as an anti-microbial agents) subsequently, and then stirred with a magnetic stirrer for about 10 minutes until homogeneous. The homogeneous PLGA solution thereafter poured on the mold (glass plate). The results showed that the greater the amount of poly vinyl alcohol (ratio 3:5 % by weight), the greater the tensile strength of the film, but the lower elongation.


Keywords: solid waste of palm starch industry; lactic acid; SSF;PLGA

Full Text:



Adney, B. and Baker, J., (2008), Measurement of Cellulase Activities,

Laboratory Analytical Procedure, the National Renewable Energy

Laboratory, Colorado, p 2.

Chairunnisa, H., Roostita, LB, and Gemilang, LUS, (2006), Use of

Starter Lactic Acid Bacteria in Fermented Milk Products' Lifihomi

"(Utilization of Lactic Acid Bacteria in Fermented Milk Product"

Lifihomi ", Journal of Animal Science, December 2006, Vol. 6 No.

, 102-107.

Erbetta, C. D. C., Alves, R. J., Resende, J. M., Freitas, R. F. S., Soasa, R. G.,2012, Synthesis and Characterization of Poly (D,L-Lactide-coGlycolide) Copolymer, Journal of Biomaterials and

Nanobiotechnology, Vol 3, Hal 208-225.

Gentile, Piergiorgio., Chiono, Valeria., Carmagnola, Irene., and Hatton, Paul. V., 2014. An Overview of Poly(lactic-co-glycolic) Acid

(PLGA)-Based Biomaterials for Bone Tissue Engineering,

International Journal of Molecular Sciences.

Litchfield, J.H., (2009), Lactic Acid, microbially Produced. Battele

Memorial Institude, Columbus, USA.

Parida, U. K., Nayak, A. K., Binhani, B. K., 2011, Synthesis and Characterization of Chitosan-Polyvinyl Alcohol Blended with Cloisite 30B for Controlled Release of the Anticancer Drug Curcumin, Journal of Biomaterials and Nanobiotechnology, Vol. 2, Hal. 414-425

Purnavita, S. and Sriyana, H.Y., (2011), Bioethanol Production from

Starch Dregs Waste Aren By Enzymatic using Selulotik microbial

extract termites, Journal of Food Technology and Agricultural

Products, Vol. 8, No. 2, Hal. 54-60.

Purnavita, S., Sriyana, H.Y., and Hartini, S., (2013), Process

Engineering Production of Lactic Acid From Waste Dregs Starch

Sugar As Raw Material Poly Lactic Acid, Momentum, Vol. 10, No.

, Hal. 14-18

Sreenath, H.K., Moldes, A.B., Koegel, R.G., And Straub, R.J. (2001),

LacticAcid Production by Simultaneous saccharification and

Fermentation of Alfalfa Fiber. Journal of Bioscience and

Bioengineering, Vol 92, No. 6, p. 518-523.

Wang, Q., Zou, D., Ma, H., and Wang, X., (2010), Simultaneous

saccharification and Fermentation of Corn Straw to Lactic Acid,

Chem. Biochem. Eng, Q. 24 (3) 371-376.

Yoon, H.H., (1997), Simultaneous saccharification and Fermentation

of Cellulose for Lactic Acid P



  • There are currently no refbacks.

Copyright (c) 2017 World Chemical Engineering Journal

WCEJ (e-ISSN: 2443-2261) is published by Chemical Engineering Department, University of Sultan Ageng Tirtayasa (UNTIRTA).

This Journal has been indexed by:

Google Scholar

Open Academic Journal Index

JIFACTOR (Journal Impact Factor)

Cite Factor 

General Impact Factor (on Progress)



Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.