Antileukemic Activity of Methanol Extract From Stem of Baccaurea macrocarpa, Syzygium jambos, Bouea macrophylla Griff., and Diospyros discolor Willd

Antoni Pardede, Rr Ariessanty Alicia Kusuma Wardhani, Emilda Frasisca

Abstract


A secondary metabolite is a compound produced by plants that are needed for its survival. Those compounds are used as attractant, repellant, and protectant. The three of them, such as color, taste, aroma, and thorns of the plants. These secondary metabolite compounds are important to be revealed. It aims to find new natural resources that are safer, more effective, and efficient in aiding the health sector, such as anticancer, antibacterial, and hepatoprotective and antioxidant properties. The research trends of natural products chemistry sourced from plants that are widely developing are extraction and biological activity, such as anticancer. In this research, the extraction of 1 kg sample was done by using maceration method and produced methanol extract of kapul (Baccaurea macrocarpa) 3.1%, jambu mawar (Syzygium jambos) 2.4%, ramania (Bouea macrophylla Griff) 9% and mentega (Diospyros discolor Willd) 2.7%, and the result of antileukemic activity of methanol extract sample (the survived HL-60 cell percentage) sequentially were 22.6%, 12.7%, 44.1% and 37.3% with the concentration of 100 µg/mL. Jambu mawar (Syzygium jambos) exhibited the highest antileukemic activity with the survived cell percentage (HL-60 cells) of 12.7% among the methanol extract of samples tested.

Keywords


Methanol extract; Baccaurea macrocarpa; Syzygium jambos; Bouea macropylla Griff; Diospyros discolor Willd

Full Text:

PDF

References


Ahmed, I. A., Mikail, M. A., Bin Ibrahim, M., Bin Hazali, N., Rasad, M. S. B. A., Ghani, R. A., Wahab, R. A., Arief, S. J., & Yahya, M. N. A. (2015). Antioxidant activity and phenolic profile of various morphological parts of underutilised Baccaurea angulata fruit. Food Chemistry, vol. 172, hh 778–787.

Fakhrudin, N., Putri, P., Sutomo, & Wahyuono, S. (2015). Antiinflamatory activity of methanolic extract of Mangifera casturi in thioglycollate-induced leukocyte migration on mice. Tradisional Medicine Journal, vol. 18, no. 3, hh 151–156.

Ganapaty, S., Thomas, P., Mallika, B., Balaji, S., Karagianis, G., & Waterman, P. (2005). Dimeric naphthoquinones from Diospyros discolor. Centre for Phytochemistry and Pharmacology Papers, vol. 33, no. 3, hh 313-315.

Gunawan, G., Chikmawati, T., Sobir, S., & Sulistijorini, S. (2016). Review: Fitokimia genus Baccaurea spp. Bioeksperimen: Jurnal Penelitian Biologi, vol. 2, no. 2, hh 96.

Imatomi, M., Novaes, P., Matos, A. P., Gualtieri, S. C. J., Molinillo, J. M. G., Lacret, R., Varela, R. M., & Macías, F. A. (2013). Phytotoxic effect of bioactive compounds isolated from Myrcia tomentosa (Myrtaceae) leaves. Biochemical Systematics and Ecology, vol. 46, hh 29–35.

Madiyawati, M., Penyang, Fauzi, F., & Triyadi, A. (2015). Karakteristik dan uji fitokimia 5 (lima) jenis tumbuhan buah eksotik dari kabupaten barito utara Kalimantan Tengah. Jurnal Daun, vol. 53, no. 9, hh 1689–1699.

Mahargyani, W. (2019). Uji Aktivitas Antidiabetes Ekstrak n-Heksan Kulit Buah Naga Merah (Hylocereus polyrhyzus). EduChemia (Jurnal Kimia Dan Pendidikan), vol. 4, no. 1, hh 13.

Ola, A. R. B., & Tawo, B. D. (2008). Identifikasi molekular dan aktivitas antikanker alkil fenol dari minyak kulit biji jambu mete (Anacardium occidentale L) asal pulau Timor Molecular identification and anticancer activity of alkylphenol from cashew nut shell oil (Anacardium occidentale). Majalah Farmasi Indonesia, vol. 19, no. 3, hh 137–144.

Pardede, A., & Koketsu, M. (2017). Antioxidant and antileukemic activity of chemical components from bark of Mangifera casturi. Comparative Clinical Pathology, vol. 26, no. 3, hh 499-504.

Pardede, A., Mashita, K., Ninomiya, M., Tanaka, K., & Koketsu, M. (2016). Flavonoid profile and antileukemic activity of Coreopsis lanceolata flowers. Bioorganic and Medicinal Chemistry Letters, vol. 26, no. 12, hh 2784-2787.

Pardede, A., Yuliar, & Rizaldi. (2019). Kimia Bahan Alam Garcinia cymosa: Taksonomi, Fitokimia, Ekstraksi, Fraksinasi dan Isolasi. (1st ed.). Universitas Islam Kalimantan MAB.

Romadanu, R., Hanggita, S., & Lestari, S. (2014). Pengujian aktivitas antioksidan ekstrak bunga lotus (Nelumbo nucifera). Jurnal FishtecH, vol. 3, no. 1, hh 1–7.

Santoni, A., Sabariah, & Efdi, M. (2015). Isolasi dan elusidasi struktur senyawa triterpenoid dari kulit batang ambacang. Jurnal Riset Kimia, vol. 9, no. 1, hh 1–8.

Sharma, R., Kishore, N., Hussein, A., & Lall, N. (2013). Antibacterial and anti-inflammatory effects of Syzygium jambos L. (Alston) and isolated compounds on acne vulgaris. BMC Complementary and Alternative Medicine, vol. 13, no. 1, hh 1.

Soetomo, S., Eviyana, E., Choironi, N. A., Dizzania, N., Fareza, M. S., & Martinus, A. (2019). Isolasi dan identifikasi senyawa aktif dari daun jambu mawar (Syzygium jambos (L.) Alston. Jurnal Sains Dan Terapan Kimia, vol. 13, no. 2, hh 59.

Sutomo, S, W., S, R., & EP, S. (2013). Isolation and identification of active compound of n-hexane from kasturi (Mangifera casturi Konsterm) against antioxidant and immunomodulatory activity. Journal of Biological Sciences, vol 13, no. 7, hh 596–604.




DOI: http://dx.doi.org/10.30870/educhemia.v5i2.8320

Refbacks



Copyright (c) 2020 Antoni Pardede, Rr Ariessanty Alicia Kusuma Wardhani, Emilda Frasisca

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

EduChemia Indexed by:

   

                                                                                                                                                                                                                                                 More Indecxing...                                                         

Creative Commons License

EduChemia: Jurnal Kimia dan Pendidikan is licensed under a Creative Commons Attribution 4.0 International License

________________________________________________________

EduChemia: Jurnal Kimia dan Pendidikan ISSN 2502-4779 (print) | ISSN 2502-4787 (online)
Published by Department of Chemistry Education - Universitas Sultan Ageng Tirtayasa
Address : Jl. Ciwaru Raya No. 25, Sempu, Kota Serang, Banten 42117, Indonesia
Email  : [email protected]