Rotavirus disease (gastroenteritis) in children with diarrhea (0-5 years): Determined prevalence in selected hospitals of Sokoto City, Nigeria

Salisu Garba; Malami Dikko; Barga Isiyaka Bala; Zayyanu Malami; Yusuf Sarkingobir; Sabiu Muhammad

doi:10.36055/jocse.v2i2.22174

Rotavirus disease (gastroenteritis) in children with diarrhea (0-5 years): Determined prevalence in selected hospitals of Sokoto City, Nigeria

Salisu Garba, Malami Dikko, Barga Isiyaka Bala, Zayyanu Malami, Yusuf Sarkingobir, Sabiu Muhammad

Abstract

Rotavirus is the most common cause of severe diarrhea among children under five years of age worldwide. This study was conducted to detect the prevalence of Rotaviruses in children attending selected hospitals in Sokoto State. Three hundred fifty stool samples were collected from diarrheic children under five years of age. Samples were analyzed for Group A rotavirus antigens using the CUSABIO Human Rotavirus (RV Ag) ELISA kit. Rotaviruses were detected in stool samples of 53/350 children, given a 15.1% prevalence, with the infection occurring throughout the study period. The percentage of Rotavirus infections was 52.8% and 47.2 % among males and females, respectively. The Rotavirus cases were significantly higher in children below two years of age 32/53 (60.4%) than children between 2-5 years of age 21/53 (39.6%). The result further showed that 35/53(66.1%) of the positive cases exhibited three major symptoms of the disease, while 13/53 (24.5%) exhibited diarrhea with either fever or vomiting, while 9.4%(5/53) showed only diarrhea. Vaccination and other related interventions, including routine diagnosis, should be provided to safeguard public health against the Rotavirus.

Rotavirus adalah penyebab paling umum diare parah pada anak di bawah lima tahun di seluruh dunia. Penelitian ini dilakukan untuk mendeteksi prevalensi Rotavirus pada anak-anak yang dirawat di rumah sakit tertentu di Negara Bagian Sokoto. Tiga ratus lima puluh sampel tinja dikumpulkan dari anak-anak di bawah usia lima tahun yang menderita diare. Sampel dianalisis untuk antigen rotavirus Grup A menggunakan kit ELISA CUSABIO Human Rotavirus (RV Ag). Rotavirus terdeteksi pada sampel tinja 53/350 anak, dengan prevalensi 15,1%, dengan infeksi terjadi sepanjang masa penelitian. Persentase infeksi Rotavirus masing-masing adalah 52,8% dan 47,2% pada laki-laki dan perempuan. Kasus Rotavirus secara signifikan lebih tinggi pada anak-anak di bawah usia dua tahun 32/53 (60,4%) dibandingkan anak-anak antara usia 2-5 tahun 21/53 (39,6%). Hasilnya lebih lanjut menunjukkan bahwa 35/53 (66,1%) dari kasus positif menunjukkan tiga gejala utama penyakit, sementara 13/53 (24,5%) menunjukkan diare disertai demam atau muntah, sedangkan 9,4% (5/53) hanya menunjukkan gejala penyakit yang sama. diare. Vaksinasi dan intervensi terkait lainnya, termasuk diagnosis rutin, harus diberikan untuk menjaga kesehatan masyarakat terhadap Rotavirus.

Keywords

Rotavirus, diarrhea, children, hospital, Sokoto, symptoms

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References

Alkali, B. R., Daneji, A. I., Magaji, A. A., Bilbis, L. S., & Bande, F. (2016). Molecular characterization of human rotavirus from children with diarrheal disease in Sokoto State, Nigeria. Molecular Biology International, vol. 2016, no. 1876065, pp. 1-9.

Afolabi, O. F., Saka, A. O., & Ojuwa, A.(2019). Serum zinc levels and clinical outcome of hospitalized Nigerian children with acute diarrhea. Niger Delta Medical Journal, vol. 3, no. 1, pp. 29-36.

Ali, S., Khan, S., Ilhan, S. N., Rauf, M., Khan, M. F., Majid, A., Dawai, F. U., Akbar, N. U. I., Ullah, R., Bari, A., & Khan, M. U.(2023). Molecular detection and prevalence of Rotavirus with acute gastroenteritis among the children of rural and urban areas. Brazilian Journal of Biology, vol. 83, no. e244365, pp. 1-9.

Kwami, W. S., Kafin, S. K., Mahmoud, M. H., Aldigeal, A. H., and Hamar, M. N. M. (2020). Molecular characterization of human Rotavirus strains circulating among children less than 5 years attended with diarrhea to Mohammed Alami Hamid Pediatric Hospital Khartoum. Saudi Journal of Biomedical Research, vol. 5, no. 6, pp. 118-124.

Ibrahim, I., Usman, R. U., Mohammed, H. I., Ishaku, D. (2021). Prevalence and predictors of Rotavirus infection among children ages 0-5 years with gastroenteritis in 2 selected healthcare centres in Keffi, Nigeria. Asian Journal of Research and Reports in Gastroenterology, vol. 5, no. 1, pp. 1-9.

Abdullahi, A., Kadarman, N., Hassan, A., & Madobi, I. S. (2015). Negative impact of abattoir activities and management in residential neighbourhoods in Kuala Terengganu, Malaysia. Int. J. Public Health Sci., vol. 4, no. 2, pp. 124-130.

Na’uzo, A. M., Tukur, D., Sufiyan, M. A. B., Stephen, A. A., Ajayi, I., Bamgboye, E., Gobir, A. A., Umeokonkwo, C. D., Abdullahi, Z., & Ajumobi, O. (2020). Adherence to malaria rapid diagnostic test result among healthcare workers in Sokoto metropolis, Nigeria. Malaria Journal, vol. 19, no. 1, pp.1-9.

Aminu, M., Ahmed, A. A, Umoh J. U., Dewar, J., Eason, M. D., & Steele A. D. (2008). Epidemiology of Rotavirus infection in North-West Nigeria. Journal of Tropical Paediatrics, vol. 54, no. 5, pp. 340-342.

Sarmukaddam, S. B., & Garad, S. G. (2004). On validity of assumptions while determining sample size. Indian. Journal Comm Med, vol. 29, no. 2, pp. 87-91.

Dorsey, M. Bass, M. D., Harry, B., & Greenberg, M. D. (2017). Detection of group A rotavirus in infants with extrahepatic biliary atresia. Journal of Infectious Disease, vol. 174, pp. 8-15.

Tate, J. E, Patel, M. M, Steele, A. D, Gentsch J. R, Payne, D. C., Cortese M. M., Nakagomi, O., Cunliffe, N. A., Jiang, B., Neuzil, K. M., de Oleivera, L. H., Glass, R. I., & Parashar, U. D. (2010). Global impact of rotavirus vaccines, Expert Review of Vaccines, vol. 9, no. 4, pp. 395-407.

Ceyhan, M., Alhan, E., Salman,N., Kurugol, Z., Yildrim, I., Celik, U., Keser, M., Koturoglu, G., Tezer, H., Bulbul, E. K., Karabocuoglu, M., Halicioglu, O., Anis, S., & Pawinski, R. (2009). Multicenter prospective study on the burden of rotavirus gasteroentiritis in Turkey, 2005-2006: A hospital based study. Journal of infectious Diseases, vol. 200, no. 1, pp. S234-238.

Parashar, U. D., Gibson, C. J., Bress, J. S., & Glass, R. I. (2006). Rotavirus and severe childhood diarrhea. Emerging Infectious Diseases, vol. 12, no. 2, pp. 304-306.

Naghipour, M., Nakagomi, T., & Nakagomi, O. (2008). Issues with reducing the rotavirus associated mortality by vaccination in developing countries. Vaccine, vol. 26, pp. 3236-3241.

Institute for Health Metrics and Evaluation (IHME). (2020). Global Burden of Disease Study 2019, [Online], Accessed at http://ghdx.healthdata.org/gbd-results-tool, Accessed on 11 July 2020.

Nobumichi, K. Mohammed, M. A., Kazunobu, K., Keiji, M., Masaho, I., & Ayako, S. (2003). Genomic diversity and Molecular epidemiology of rotaviruses, Research Signpost Journal; vol. 69, no. 23, pp. 75-89.

Sarkingobir, Y., Hamza, A., Dikko, M., Abubakar, M., Yabo, A. G., & Muhammad, B. I. (2022). Antibacterial study of guava leaves on some enteric bacteria (E. coli and Shigella dysentriae) from Sokoto, Nigeria. International Research Journal of Science, Technology, Education, and Management, vol. 2, no. 4, pp. 1-7.

Pennap, G., & Umoh, J. (2010). The prevalence of group A rotavirus infection and some risk factors in pediatric diarrhea in Zaria, North central Nigeria. African Journal of Microbiology Research, vol. 4, no. 14, pp. 1532–1536.

Juaidu, S. A., Umeh, C., Olabode, A. O., & Banda, J. M. (2011). Incidence of rotavirus infection in children with gasteroenteritis attending Jos University teaching hospital. Nigeria. Journal of Virology, vol. 8, no. 1, pp. 233.

Page, N., Pager, C., & Steele, A. D. (2010). Characterization of rotavirus strains detected in Windhoek, Namibia during 1998-1999. Journal Infectious Disease, vol. 202, vol. 1, pp. 162-167

Muhammed, A. A., Aminu, M., Ado, S. A., Jatau, E. D., & Esona, M. D. (2016). Prevalence of Rotavirus among children under five years of age with diarrhea in Kaduna State, Nigeria. Nigerian Journal of Paediatrics, vol. 43, no. 4, pp. 264–268.

Wada-Kura, A. (2011). Molecular characterisation of Rotaviruses detected in children under the age of five years with diarrhoea in Kano State-Nigeria, Doctoral Dissertation, Nigeria: Ahmadu Bello University.

Audu, R. Omilabu, S. A., Peenze, I., & Steele D. (2002). Viral diarrhoea in young children in two districts in Nigeria. Central African Journal of Medicine, vol. 48, no. 5-6, pp. 59–63.

Tagbo, B. N., Mwenda, J. M., Armah, G., Obidike, E. O., Okafor, U. H., Oguonu, T., Ozumba, U. C., Eke, C. B., Chukwubuike, C., Edelu, B. O., Ezeonwu, B. U., Amadi, O., Okeke, I. B., Nnani, O. R., Ani, O. S., Ugwuezeonu, I., Benjamin-Pujah, C., Umezinne, U., Ude, N., Nwodo, C., Ezeonyebuchi, M. C., Umesie, E., Okafor, V., Ogude, N., Osarogborum, V. O., Ezebilo, S. K., Goitom, W. G., Abanida, E. A., Elemuwa, C., Nwagbo, D. F. (2014). Epidemiology of Rotavirus Diarrhea among children younger than five years in Enugu, South East Nigeria. Pediatr. Infec. Disease Journal, vol. 33, pp. 19-22.

Adiku, T. K., Dove, W., Grosjean, P., Combe, P., Nakagomi, T., Nakagomi, O., Hart, C. A., & Cunliffe, N. A. (2010). Molecular characterization of rotavirus strains circulating among children with acute gastroenteritis in Madagascar during 2004–2005. Journal of Infectious Diseases, vol. 202, no. 1, pp. 175-179.

Armah, G. E., Pager, C. T., & Asmah, R. H. (2001). Prevalence of unusual human rotavirus strains in Ghanaian children. Journal of Medical Virology, vol. 63, no. 1, pp. 67–71.

Potgieter, N., De Beer, M. C., Taylor, M. B., & Duncan, S. A. (2010). Prevalence and diversity of rotavirus strains in children with acute diarrhea from rural communities in the Limpopo Province, South Africa, from 1998 to 2000. Journal of Infectious Diseases, vol. 202, no. 1, pp. 148-155.

Nimzing,, L, Geyer, A., Sebata, T., deBeer, M., Angyo, I., & Gomwalk, N. E., (2000), Epidemiology of Adenoviruses and and Rotaviruses identified in young children in Jos Nigeria. South Africa Journal Epidemiology. Infectious, pp. 15, no. 2, pp. 40-42.

Kuta, F. A., Uba, A., Nimzing, L., & Damisa, D. (2013), Molecular identification of rotavirus strains associated with diarrhea among children in Kwara state, Nigeria. Bayero Journal of Pure and Applied Sciences, vol. 6, no. 2, pp. 23-26.

Ansari, S., Sherchand, J. B., Rijal, B. P., Parajuli, K., Mishra, S. K., Dahal, R. K., Shrestha, S., Tandukar, S., Chaudhary, R., Kattel, H. P., Basnet, A., & Pokhrel, B. M. (2013). Characterizations of Rotavirus causing acute diarrhea in Kathmandu, Nepal, Showing a dominance of serotype G12. Journal of Medical Microbiology, vol. 62, no. 1, pp. 114-12

Shariff, M., Deb, M., & Singh, R. (2003). A study of diarrhea among children in eastern Nepal with special reference to rotavirus. Indian Journal Medical Microbiology, vol. 21, no. 2, pp. 87-90

Rerksuppaphol, S., & Rerksuppaphol, L. (2011). Prevalence and clinical manifestations of rotavirus diarrhea in children of rural area of Thailand. International Journal of Collaborative Research on Internal Medicine and Public Health, vol. 3, no. 9, pp. 695-702.

Bernstein, D. I,. & Ward, R. L. (2004). Rotavirus in Paediatric Infectious Diseases 5th Edition. Philadelphia: PA. Saunders.

Staat, M, A., Azimi, P. H., Berke, T., Roberts, N., Bernstein D. I., Ward, R. L., Pickering, L. K., & Matson, D. O. (2014). Clinical presentations of rotavirus infections among hospitalized children. Journal of Infectious Disease, vol. 21, no. 3, pp. 221-227.

Offit, P. A. (2001). Gastroenteritis Viruses. New York: Wiley. ISBN: 978-0-471-49663-2.

Lewis, H. M., Parry, J. V, Davies, H. A., Parry, R. P., Mott, A., Dourmashkin, R. R., Sanderson, P. J., Tyrrell, D. A., & Valman, H. B. (1979). A years’ experience of the rotavirus syndrome and its association with respiratory illness. Archives of Disease in Childhood; vol. 54, no. 5, pp. 339-346.

Santosham, M., Yolken, R. H., Quiroz, E., Dillman, L., Oro, G., Reeves, W. C., & Sack, R. B. (1983): Detection of rotavirus in respiratory secretions of children with pneumonia. The Journal of Pediatrics, vol. 103, no. 4, pp. 583-585.

Zheng, B. J., Chang, R. X., Ma, G. Z., Xie, J. M., Liu, Q., Liang, X. R., & Ng, M. H. (1991). Rotavirus infection of the oropharynx and respiratory tract in young children. Journal of Microbiology Immunology, vol. 34, no. 1, pp. 29-37.

Thomas, C., Breeze, P., Strong M., Brennan, A., Norman, P., Cameroon, D., & Epton, T. (2016). The cost effectiveness of an updated theory-based online health behavior intervention for new university students:U@Uniz. Journal of Public Health and Epidemiology, vol. 8, no. 10, pp. 191-203.

DOI: http://dx.doi.org/10.36055/jocse.v2i2.22174

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