A review of encapsulation using emulsion crosslinking method

Jayanudin Jayanudin, Heri Heriyanto

Abstract


Encapsulation is a process to protect active components or other materials in the form of liquids, solids, and gases which are sensitive to the environment using coating materials. Encapsulation can be used for the pharmaceutical, food, beverage, textile, and other industries. The encapsulation method has been developed depending on the active ingredient being protected and its function. The encapsulation method is generally divided into chemical and mechanical methods. This review aims to explain the emulsion crosslinking which is one of the encapsulation methods. This method was easy and simple, just add a crosslink agent to the emulsion and then the microparticles formed were washed, filtered, and dried. This review also reports several encapsulation studies using the emulsion crosslinking method.

Full Text:

PDF

References


Bhardwaj S.B., Shukla A.J., Collins C.C. 1995. Effect of Varying Drug Loading on Particle-Size Distribution and Drug-Release Kinetics of Verapamil Hydrochloride Microspheres Prepared with Cellulose Esters. Journal of Microencapsulation. Vol. 12, No.1, pp. 71-81

Biswal I., Dinda A., Mohanty S., Dhara M., Das D., Chowdary K.A., Si S. 2011. Influence of Drug/Polymer Ratio on the Encapsulation Efficiency of Highly Hydrophilic Drug. Asian Journal of Chemistry. Vol. 23, No.5, pp. 1973-1978

Butler M.F., Ng Y.F., and Pudney P.D.A. 2003. Mechanism and kinetics of the crosslinking reaction between biopolymers containing primary amine groups and genipin. Journal of Polymer Science. Part A: Polymer Chemistry. Vol.41, No. 24, pp. 3941–3953

Campos E., Coimbra P., Gil M.H. 2013. An Improved Method for Preparing Glutaraldehyde Cross-linked Chitosan-Poly(vinyl alcohol) Microparticles. Polymer Bulletin. Vol. 70, No.2, pp. 549-561

Chang C.M and Bodmeier R. 1996. Organic Solvent-Free Polymeric Microspheres Prepared From Aqueous Colloidal Polymer Dispersions by a W/O-Emulsion Technique. International Journal of Pharmaceutics. Vol. 130, No.2, pp. 187-194

Gonçalves V.L., Laranjeira M.C.M., Fávere V.T. 2005. Effect of Crosslinking Agents on Chitosan Microspheres in Controlled Release of Diclofenac Sodium. Polímeros: Ciência e Tecnologia. Vol.15, No.1, pp. 6-12

Hussain M.R., Devi R.R., Maji T.K. 2012. Controlled release of urea from chitosan microspheres prepared by emulsification and cross-linking method. Iranian Polymer Journal, Vol. 21, No. 8, pp. 473-479

Jameela S.R., Jayakrishnan A. 1995. Glutaraldehyde Cross-linked Chitosan Microspheres as a Long Acting Biodegradable Drug Delivery Vehicle: Studies on the In Vitro Release of Mitoxantrone and In Vivo Degradation of Microspheres in Rat Muscle. Biomaterials. Vol.16, No.10, pp. 769-775

Jayanudin., Rochmadi., Fahrurrozi M., Wirawan S.K. 2016. Microencapsulation Technology of Ginger Oleoresin with Chitosan as Wall Material: A Review. Journal of Applied Pharmaceutical Science, Vol. 6, No.12, pp. 209-223.

Jayanudin., Rochmadi., Fahrurrozi M., Wirawan S.K. 2019. Preparation of Chitosan Microcapsules Containing Red Ginger Oleoresin Using Emulsion Crosslinking Method. Journal of Applied Biomaterials & Functional Materials. Vol. 17, No. 1, pp. 1-9

Jayanudin. 2019. Mikroenkapsulasi Oleoresin Jahe Merah (Zingiber Offcinale Var Rubrum) Sebagai Antioksidan Alami Dengan Penyalut Kitosan Menggunakan Metode Crosslink Emulsi. Dissertation. Chemical Engineering Department, Universitas Gadjah Mada, Yogyakarta

Jeyanthi R., Mehta R.C., Thanoo B.C., DeLuca PP. 1997. Effect of Processing Parameters on the Properties of Peptidecontaining PLGA Microspheres. Journal of Microencapsulation. Vol. 14, No.2, pp.163–174

Jyothi N.V.N., Prasanna P.M., Sakarkar S.N., Prabha K.S., Ramaiah P.S., Srawan G.Y. 2010. Microencapsulation Techniques, Factors Influencing Encapsulation Efficiency. Journal of Microencapsulation. Vol. 27, No.3, pp. 187-197

Latha M.S., Jayakrishnan A. 1994. Glutaraldehyde Cross‐linked Bovine Casein Microspheres as a Matrix for the Controlled Release of Theophylline: In‐vitro Studies. Journal of Pharmacy and Pharmacology. Vol. 46, No. 1, pp. 8-13

Longo W.E., Iwata H., Lindheimer T.A., Goldberg E.P. 1982. Preparation of Hydrophilic Albumin Microspheres Using Polymeric Dispersing Agents. Journal of Pharmaceutical Science. Vol.71, No.12, pp. 1323-1328

Luo M, Peng H, Deng Z, Yin Z, Zhao Q, Xiong H. 2015. Preparation and Characterization of Genipin-Crosslinked Chitosan Microspheres for the Sustained Release of Salidroside. International Journal of Food Engineering. Vol. 11, No.3, pp. 323-33

Manickam B., Sreedharan R., Elumalai M. 2014. ‘Genipin’ – The Natural Water Soluble Cross-linking Agent and Its Importance in the Modified Drug Delivery Systems: An Overview. Current Drug Delivery. Vol. 11, No. 1, pp. 139-145

Manjanna KM., Shivakumar B., Kumar T.M.P. 2010. Microencapsulation: An Acclaimed Novel Drug-Delivery System for NSAIDs in Arthritis. Critical Reviews in Therapeutic Drug Carrier Systems. Vol. 27, No.6, pp. 509-545

Mehta R.C., Thanoo B.C., DeLuca P.P. 1996, Peptide Containing Microspheres From Low Molecular Weight and Hydrophilic Poly (D,L-lactide-co-glycolide). Journal Control Release. Vol.41, No.3, pp. 249–257

Miloševic R., Kašikovic N., Pavlovic Z., Elesini U.S., Urbas R. 2016. Microcapsules Properties And Their Application Using Different Printing Techniques. XI Conference Of Chemists, Technologists And Environmentalists Of Republic Of Srpska. Teslic, Bosnia and Herzegovina, 18- 19 November 2016

Minemoto Y., Hakamata K., Adachi S., Matsuno, R. 2002. Oxidation of Linoleic Acid Encapsulated With Gum Arabic or Maltodextrin by Spray-Drying. Journal of Microencapsulation. Vol.19, No.2, pp. 181−189

Mishra, M, 2016, Handbook of Encapsulation and Controlled Release. CRC Press Taylor & Francis Group. New York

Mitra A and Dey B. 2011. Chitosan Microspheres in Novel Drug Delivery Systems. Indian Journal of Pharmaceutical Sciences. Vol. 4, No.73, pp. 355-366

Monteiro O.A.C and Airoldi C. 1999. Some studies of crosslinking chitosan-glutaraldehyde interaction in a homogeneous system. International Journal of Biological Macromolecules. Vol. 26, No.2-3, pp. 119-128

Muzzarelli R.A.A. 2009. Genipin-crosslinked chitosan hydrogels as biomedical and pharmaceutical aids. Carbohydrate Polymers. Vol. 77, No. 1, pp. 1-9

Nishi C, Nakajima N, Ikada Y. 1995. In vitro evaluation of cytotoxicity of diepoxy compounds used for biomaterial modification. Journal of Biomedical Materials Research. Vol. 29, No.7, pp. 829-34

Ofokansi K.C., Kenechukwu F.C., Isah A.B., Okigbo E.L. 2013. Formulation and Evaluation of Glutaraldehyde-Crosslinked Chitosan Microparticles for the Delivery of Ibuprofen. Tropical Journal of Pharmaceutical Research. Vol.12, No.1, pp. 19-25

Pal K., Paulson A.T., and Rousseau, D. 2013. Biopolymers in Controlled-Release Delivery Systems. In. Ebnesajjad S (eds). Handbook of Biopolymers and Biodegradable Plastics. 1st Edition. Elsevier, pp. 338-340

Panchal AM, Patel KS, Patel MB, Oza PJ, Jobanputra UM, Meghnathi UR. 2012. Preparation and Evaluation Glutaraldehyde Cross Linked Chitosan Microspheres Containing Rivastigmine Tartrate. International Journal for Pharmaceutical Research Scholars. Vol. 1, No.2, pp. 206-213

Rafati H., Coombes A.G.A., Adler J., Holland J., Davis S.S. 1997. Protein-Loaded PLGA Microparticles for Oral Administration: Formulation, Structural and Release Characteristics. Journal of Controlled Release. Vol.43, No.1, pp. 89–102

Ramachandran S., Thirumurugan S., Dhanaraju M.., 2011. Development and Evaluation of Biodegradable Chitosan Microspheres Loaded with Ranitidine and Cross Linked with Glutaraldehyde. Tropical Journal of Pharmaceutical Research. Vol.10, No.3, pp. 309-316

Schlicher E.J.A.M., Postma N.S., Zuidema J., Talsma H., Hennink W.E. 1997. Preparation and Characterization of Poly(D,L-lactic-co-glycolic acid) Microspheres Containing Desferrioxamine. International Journal of Pharmaceutics. Vol. 153, No.2, pp. 235–245

Sung H.W., Huang R.N., Huang L.L.H., and Tsai C.C. 1999. In vitro evaluation of cytotoxicity of a naturally occurring crosslinking reagent for biological tissue fixation. Journal of Biomaterials Science. Polymer Edition, Vol. 10, No.1, pp. 63–78

Thanoo B.C., Sunny M.C., Jayakrishnan A. 1992. Cross-linked Chitosan Microspheres: Preparation and Evaluation as a Matrix for the Controlled Release of Pharmaceuticals. Journal of Pharmacy and Pharmacology. Vol. 44, No.4, pp. 283-286

Zhu Y., Park M.B.C. 2007. Density quantification of collagen grafted on biodegradable polyester: its application to esophageal smooth muscle cell. Analytical Biochemistry. Vol. 363, No.1, pp.119-127




DOI: http://dx.doi.org/10.62870/wcej.v5i2.12312

Refbacks

  • There are currently no refbacks.


Copyright (c) 2021 World Chemical Engineering Journal

WCEJ (e-ISSN: 2443-2261) is published by Chemical Engineering Department, Universitas Sultan Ageng Tirtayasa (UNTIRTA).

This Journal has been indexed by:

  1. Google Scholar
  2. Garuda
  3. Dimensions
  4. Crossref
  5. Open Academic Journal Index
  6. Journal Impact Factor
  7. Cite Factor 
Archives: Resources | Dimensions CrossrefJIFACTOR, Journal Indexing  

 

 

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.