Physical Stability Evaluation of Cassava Leaf Aqueous Extract Emulgel (Manihot esculenta)

Havizur Rahman, Indah Sari, Fathnur Sani

Abstract


Cassava leaves contain various secondary metabolites such as flavonoids and saponins that can be used as anti-inflammatory and antibacterial.This study aims to determine the physical stability of cassava leaf extract emulgel (Manihot esculenta), which can be used as an anti-inflammatory. Emulgel was made in 3 formulas with variations in the concentration of cassava leaf extract, namely 2.5%, 5%, and 7.5%. Emulgel stability tests include organoleptic tests, homogeneity, viscosity, dispersibility, adhesion, and pH. Stability testing using the cycling test method for 12 days of storage at temperatures 4oC and 40oC. This study showed cassava leaf extract can be formulated as emulgel and has good stability after storage at extreme temperatures for 12 days. Emulgel formulations from cassava leaf extract have good stability and can be anti-inflammatory.


Keywords


Cassava leaves, emulgel, stability

Full Text:

PDF

References


Ali Khan, B., Ullah, S., Khan, M. K., Alshahrani, S. M., & Braga, V. A. (2020). Formulation And Evaluation Of Ocimum Basilicum-Based Emulgel For Wound Healing Using Animal Model. Saudi Pharmaceutical Journal : SPJ, 28(12), 1842. Https://Doi.Org/10.1016/J.JSPS.2020.11.011

Ali, M. H. M., & Ali, W. K. (2019). Preparation And Evaluation Of Emulgel As Topical Drug Delivery For Nimesulide By Using Conventional Emulsion. Al Mustansiriyah Journal Of Pharmaceutical Sciences, 19(4), 16–26. Https://Doi.Org/10.32947/AJPS.V19I4.629

Bahekar, S. E., & Kale, R. S. (2015). Antidiarrheal Activity Of Ethanolic Extract Of Manihot Esculenta Crantz Leaves In Wistar Rats. Journal Of Ayurveda And Integrative Medicine, 6(1), 35. Https://Doi.Org/10.4103/0975-9476.146542

Bahekar, S., & Kale, R. (2012). Phytopharmacological Aspects Of Manihot Esculenta Crantz ( Cassava ) - A Review. Journal Of Pharmaceutical Dan Medical Sciences, 2(1).

Bokanisereme, Yusuf, U. F., & Okechukwu, P. N. (2013). Anti-Inflammatory, Analgesic And Anti - Pyretic Activity Of Cassava Leaves Extract. Asian Journal Of Pharmaceutical And Clinical Research, 6(4), 89–92.

Daud, N. S., & Suyanti, E. (2017). Formulasi Emulgel Antijerawat Minyak Nilam ( Patchouli Oil ) Menggunakan Tween 80 Dan Span 80 Sebagai Pengemulsi Dan HPMC Sebagai Basis Gel. Jurnal Mandala Pharmacon Indonesia, 3(2), 90–95.

Himawan, R. D. (2020). Uji Aktivitas Antiinflamasi Ekstrak Etanol Daun Singkong (Manihot Esculenta Crantz.) Terhadap Tikus Jantan Yang Diinduksi Karagenan. Skripsi.

Kalayi, M., Yeğen, G., Üstündağ Okur, N., & Aksu, B. (2022). Evaluation Of Emulgel Formulations Contain Diclofenac Sodium Via Quality By Design Approach. Https://Doi.Org/10.29228/Jrp.143

Karande, P., & Mitragotri, S. (2009). Enhancement Of Transdermal Drug Delivery Via Synergistic Action Of Chemicals. Biochimica Et Biophysica Acta - Biomembranes, 1788(11), 2362–2373. Https://Doi.Org/10.1016/J.BBAMEM.2009.08.015

Megawati, S., Nur’aini, & K., D. (2020). Uji Efektivitas Gel Ekstrak Etanol 96% Daun Singkong (Manihot Esculenta Crantz.) Pada Penyembuhan Luka Sayat Kelinci Jantan Galur New Zealand White. Jurnal Farmagazine, 7(1).

Melani Hariyadi, D., Rosita, N., Sudarma, S., & Rezania, D. (2022). Virgin Coconut Oil Emulgel: Effect Of VCO And Carbopol 940 Concentration On Characterization And Antibacterial Activity. Research J. Pharm. And Tech, 15(5). Https://Doi.Org/10.52711/0974-360X.2022.00345

Mustarichie, R., Sulistyaningsih, S., & Runadi, D. (2020). Antibacterial Activity Test Of Extracts And Fractions Of Cassava Leaves (Manihot Esculenta Crantz) Against Clinical Isolates Of Staphylococcus Epidermidis And Propionibacterium Acnes Causing Acne. International Journal Of Microbiology, 2020. Https://Doi.Org/10.1155/2020/1975904

Nurdianti, L., & Aji, N. (2018). Evaluasi Sediaan Emulgel Anti Jerawat Tea Tree ( Melaleuca Alternifolia ) Oil Dengan Menggunakan Hpmc Sebagai Gelling Agent. Pharmacopolium, 1(1), 23–31.

Putranti, W., Dewi, N. A., & Widiyastuti, L. (2018). Standardisasi Ekstrak Dan Karakterisasi Formula Emulgel Ekstrak Rimpang Lengkuas (Alpinia Galanga (L.) Willd). Jurnal Farmasi Sains Dan Komunitas, 15(2), 81–91.

Riski, R., Umar, A. H., & Rismadani. (2016). Formulasi Emulgel Antiinflamasi Dari Ekstrak Temulawak ( Curcuma Xanthorrhiza Roxb ). Journal Of Pharmaceutical And Medicinal Sciences, 1(2), 1–4.

Sahreni, S., Isramilda, & Sururi, M. R. (2020). Uji Aktivitas Antibakteri Ekstrak Etanol Daun Singkong(Manihot Esculenta)Terhadap Pertumbuhan Staphylococcus Aureusdan Escherichia Coli. Ibnu Sina: Jurnal Kedokteran Dan Kesehatan-Fakultas Kedokteran Universitas Islam Sumatera Utara, 19(1), 22–27.

Shaik, N. B., Gera, S., Kukati, L., & Goverdhanam, H. (2019). Formulation And Evaluation Of Emulgel Of Flurbiprofen. International Research Journal Of Pharmacy, 10(8), 68–76. Https://Doi.Org/10.7897/2230-8407.1008248

Shokri, J., Azarmi, S., Fasihi, Z., Hallaj-Nezhadi, S., Nokhodchi, A., & Javadzadeh, Y. (2012). Effects Of Various Penetration Enhancers On Percutaneous Absorption Of Piroxicam From Emulgels. Research In Pharmaceutical Sciences, 7(4), 225. /Pmc/Articles/PMC3523414/

Siddhant Yadav, S. W. M. I. S. R. (2017). Topical Emulgel Of Tolnaftate With Penetration Enhancer: Development, Characterisation And Antifungal Activity. Https://Doi.Org/10.5281/ZENODO.1038500

Swastika, A., Mufrod, & Purwanto. (2013). Aktivitas Antioksidan Krim Ekstrak Sari Tomat (Solanum Lycopersicum L.). Trad. Med. J., 1(1).

Tao, H., Cui, B., Zhang, H., Bekhit, A. E. D., & Lu, F. (2019). Identification And Characterization Of Flavonoids Compounds In Cassava Leaves (Manihot Esculenta Crantz) By HPLC/FTICR-MS. International Journal Of Food Properties, 22(1), 1134–1145. Https://Doi.Org/10.1080/10942912.2019.1626879/SUPPL_FILE/LJFP_A_1626879_SM2365.DOCX

Tirmiara, N. (2018). Formulasi Dan Evaluasi Sediaan Nanoemulsi Gel Vitamin E (Alfa Tokoferol) Sebagai Skin Anti- Aging. Talenta Conference Series: Tropical Medicine (TM).




DOI: http://dx.doi.org/10.30870/educhemia.v8i1.15898

Refbacks

  • There are currently no refbacks.


Copyright (c) 2023 havizur rahman

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

EduChemia Indexed by:

   

                                                                                                                                                                                                                                                 More Indecxing...                                                         

Creative Commons License

EduChemia: Jurnal Kimia dan Pendidikan is licensed under a Creative Commons Attribution 4.0 International License

________________________________________________________

EduChemia: Jurnal Kimia dan Pendidikan ISSN 2502-4779 (print) | ISSN 2502-4787 (online)
Published by Department of Chemistry Education - Universitas Sultan Ageng Tirtayasa
Address : Jl. Ciwaru Raya No. 25, Sempu, Kota Serang, Banten 42117, Indonesia
Email  : [email protected]